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Abcf1 Gene Detail
Summary
  • Symbol
    Abcf1
  • Name
    ATP-binding cassette, sub-family F member 1
  • Synonyms
    Abc50, D17Wsu166e, GCN20
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351658
    NCBI Gene: 224742
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:36267711-36280642 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.80 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351658
 protein coding gene Chr17:36267711-36280653 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023663
 protein coding gene Chr17:36171656-36188285 (-)
A/J MGP_AJ_G0023618
 protein coding gene Chr17:35046938-35059841 (-)
AKR/J MGP_AKRJ_G0023588
 protein coding gene Chr17:35482513-35495459 (-)
BALB/cJ MGP_BALBcJ_G0023623
 protein coding gene Chr17:35188449-35201288 (-)
C3H/HeJ MGP_C3HHeJ_G0023389
 protein coding gene Chr17:35937800-35951729 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024065
 protein coding gene Chr17:37644915-37657930 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021545
 protein coding gene Chr17:33035747-33048420 (-)
CAST/EiJ MGP_CASTEiJ_G0022880
 protein coding gene Chr17:36052621-36065461 (-)
CBA/J MGP_CBAJ_G0023367
 protein coding gene Chr17:39232713-39245675 (-)
DBA/2J MGP_DBA2J_G0023491
 protein coding gene Chr17:34342968-34355807 (-)
FVB/NJ MGP_FVBNJ_G0023462
 protein coding gene Chr17:34140437-34153611 (-)
LP/J MGP_LPJ_G0023571
 protein coding gene Chr17:36548421-36561404 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023483
 protein coding gene Chr17:37997097-38009976 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024108
 protein coding gene Chr17:35788221-35804047 (-)
PWK/PhJ MGP_PWKPhJ_G0022631
 protein coding gene Chr17:33207754-33220928 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022450
 protein coding gene Chr17:33831205-33844001 (-)
WSB/EiJ MGP_WSBEiJ_G0022946
 protein coding gene Chr17:35939290-35952124 (-)



Homology
more
  • Human Ortholog
    ABCF1, ATP binding cassette subfamily F member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCF1, ATP binding cassette subfamily F member 1
  • Synonyms
    ABC27, ABC50
  • Links
    NCBI Gene ID: 23
    neXtProt AC: NX_Q8NE71
    UniProt: Q8NE71

  • Chr Location
    6p21.33; chr6:30571393-30597179 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display lethality shortly after implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    56
  • cDNA Data
    245
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 224742 NCBI Gene Model | MGI Sequence Detail 12932 C57BL/6J ±  kb
transcript NM_013854 RefSeq | MGI Sequence Detail 3207 Not Specified  
polypeptide Q6P542 UniProt | EBI | MGI Sequence Detail 837 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000003569 ATP-binding cassette sub-family F member 1
    (term hierarchy)
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR003439 ABC transporter-like, ATP-binding domain
    IPR017871 ABC transporter-like, conserved site
    IPR050611 ATP-binding cassette sub-family F member, EF3 subfamily
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
  • GlyGen
    Q6P542 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 247
    cDNA 245
    Primer pair 1
    Other 1

    Microarray probesets 10
Other
Accession IDs
less
MGD-MRK-36426, MGI:107849, MGI:2147001
References
more
  • Summaries
    All 46
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory