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Skp2 Gene Detail
Summary
  • Symbol
    Skp2
  • Name
    S-phase kinase-associated protein 2
  • Synonyms
    4930500A04Rik, FBXL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351663
    NCBI Gene: 27401
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr15:9112073-9155512 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 3.84 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1230 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351663
 protein coding gene Chr15:9112070-9155512 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0021671
 protein coding gene Chr15:6029046-6073102 (-)
AKR/J MGP_AKRJ_G0021649
 protein coding gene Chr15:6087223-6130926 (-)
BALB/cJ MGP_BALBcJ_G0021678
 protein coding gene Chr15:5937728-5982395 (-)
C3H/HeJ MGP_C3HHeJ_G0021454
 protein coding gene Chr15:6138434-6182746 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0019654
 protein coding gene Chr15:5594980-5638597 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0021423
 protein coding gene Chr15:6550216-6602063 (-)
DBA/2J MGP_DBA2J_G0021547
 protein coding gene Chr15:5909749-5953724 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0020551
 protein coding gene Chr15:6022542-6072124 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SKP2, S-phase kinase associated protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SKP2, S-phase kinase associated protein 2
  • Synonyms
    FBL1, FBXL1, FLB1, p45
  • Links
    NCBI Gene ID: 6502
    neXtProt AC: NX_Q13309
    UniProt: Q13309

  • Chr Location
    5p13.2; chr5:36151989-36196849 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SKP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced body weight, enlarged cell and nuclear sizes, polyploidy, reduced cell growth rate, overduplication of centrosomes, increased apoptosis rate, delayed wound healing, and aberrant immunoglobulin V(D)J recombination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    15
  • cDNA Data
    96
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054115 Ensembl Gene Model | MGI Sequence Detail 43440 C57BL/6J ±  kb
    transcript ENSMUST00000096482 Ensembl | MGI Sequence Detail 3118 Not Applicable  
    polypeptide ENSMUSP00000094225 Ensembl | MGI Sequence Detail 424 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 97
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1922284
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 46
    • Earliest
      J:54020 Hatakeyama S, et al., Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3859-63
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory