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Cxcl10 Gene Detail
Summary
  • Symbol
    Cxcl10
  • Name
    C-X-C motif chemokine ligand 10
  • Synonyms
    C7, CRG-2, gIP-10, Ifi10, INP10, IP-10, IP10, mob-1, Scyb10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352450
    NCBI Gene: 15945
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:92494497-92496748 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 46.57 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    206 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352450
 protein coding gene Chr5:92494497-92496748 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029750
 protein coding gene Chr5:93530797-93533077 (-)
A/J MGP_AJ_G0029716
 protein coding gene Chr5:89813797-89816048 (-)
AKR/J MGP_AKRJ_G0029662
 protein coding gene Chr5:92754345-92756591 (-)
BALB/cJ MGP_BALBcJ_G0029726
 protein coding gene Chr5:90698217-90700463 (-)
C3H/HeJ MGP_C3HHeJ_G0029449
 protein coding gene Chr5:93157324-93159570 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030180
 protein coding gene Chr5:97242477-97245742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027416
 protein coding gene Chr5:85464649-85466924 (-)
CAST/EiJ MGP_CASTEiJ_G0028859
 protein coding gene Chr5:92536995-92539256 (-)
CBA/J MGP_CBAJ_G0029419
 protein coding gene Chr5:100616202-100618448 (-)
DBA/2J MGP_DBA2J_G0029563
 protein coding gene Chr5:89862074-89864320 (-)
FVB/NJ MGP_FVBNJ_G0029522
 protein coding gene Chr5:88706997-88709243 (-)
LP/J MGP_LPJ_G0029651
 protein coding gene Chr5:93895589-93899232 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029551
 protein coding gene Chr5:105530034-105533430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030214
 protein coding gene Chr5:92280802-92283053 (-)
PWK/PhJ MGP_PWKPhJ_G0028578
 protein coding gene Chr5:88927014-88929302 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028413
 protein coding gene Chr5:91644919-91647173 (-)
WSB/EiJ MGP_WSBEiJ_G0028938
 protein coding gene Chr5:92749768-92752014 (-)



Homology
more
  • Human Ortholog
    CXCL10, C-X-C motif chemokine ligand 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CXCL10, C-X-C motif chemokine ligand 10
  • Synonyms
    C7, crg-2, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10
  • Links
    NCBI Gene ID: 3627
    neXtProt AC: NX_P02778
    UniProt: P02778

  • Chr Location
    4q21.1; chr4:76021118-76023497 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CXCL10 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygouse for disruptions of this gene have immune system abnormalities leading to increased susceptibility toautoimmune disease and to some viral infections.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    100
  • cDNA Data
    50
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15945 NCBI Gene Model | MGI Sequence Detail 2252 C57BL/6J ±  kb
    transcript NM_021274 RefSeq | MGI Sequence Detail 1120 ZRU/MplStud  
    polypeptide P17515 UniProt | EBI | MGI Sequence Detail 98 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 1
      cDNA 53
      Primer pair 7
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11217, MGI:96424
    References
    more
    • Summaries
      All 231
      Developmental Gene Expression 29
      Gene Ontology 15
      Phenotypes 77
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory