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Nr1h2 Gene Detail
Summary
  • Symbol
    Nr1h2
  • Name
    nuclear receptor subfamily 1, group H, member 2
  • Synonyms
    LXRB, LXRbeta, RIP15, Unr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352463
    NCBI Gene: 22260
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44199040-44203375 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352463
 protein coding gene Chr7:44199040-44204928 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032169
 protein coding gene Chr7:44726124-44730459 (-)
A/J MGP_AJ_G0032148
 protein coding gene Chr7:43906715-43911050 (-)
AKR/J MGP_AKRJ_G0032084
 protein coding gene Chr7:45111859-45116194 (-)
BALB/cJ MGP_BALBcJ_G0032160
 protein coding gene Chr7:43904226-43908561 (-)
C3H/HeJ MGP_C3HHeJ_G0031876
 protein coding gene Chr7:45602164-45606499 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032652
 protein coding gene Chr7:46985585-46989920 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029666
 protein coding gene Chr7:46491692-46496043 (-)
CAST/EiJ MGP_CASTEiJ_G0031204
 protein coding gene Chr7:36985532-36989867 (-)
CBA/J MGP_CBAJ_G0031840
 protein coding gene Chr7:48525184-48529519 (-)
DBA/2J MGP_DBA2J_G0031998
 protein coding gene Chr7:43580442-43584781 (-)
FVB/NJ MGP_FVBNJ_G0031949
 protein coding gene Chr7:43323817-43328152 (-)
LP/J MGP_LPJ_G0032076
 protein coding gene Chr7:45410564-45414899 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031986
 protein coding gene Chr7:47259969-47264304 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032668
 protein coding gene Chr7:44332923-44337258 (-)
PWK/PhJ MGP_PWKPhJ_G0030927
 protein coding gene Chr7:36929021-36933360 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030764
 protein coding gene Chr7:32338091-32342422 (-)
WSB/EiJ MGP_WSBEiJ_G0031321
 protein coding gene Chr7:44789937-44794272 (-)



Homology
more
  • Human Ortholog
    NR1H2, nuclear receptor subfamily 1 group H member 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR1H2, nuclear receptor subfamily 1 group H member 2
  • Synonyms
    LXR-b, LXRB, NER, NER-I, RIP15, UNR
  • Links
    NCBI Gene ID: 7376
    neXtProt AC: NX_P55055
    UniProt: P55055

  • Chr Location
    19q13.33; chr19:50329653-50383388 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human NR1H2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 5 alleles in 6 genetic backgrounds
    60 phenotypes from multigenic genotypes
    165 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations cause altered lipid, cholesterol and glucose metabolism and may lead to elevated cartilage matrix catabolism and PGE2 production, lipid-laden uterus myocytes and Sertoli cells, impaired uterus contractility and parturition, and higher susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    86
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    794
  • Tissues
    73
  • cDNA Data
    137
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060601 Ensembl Gene Model | MGI Sequence Detail 4336 C57BL/6J ±  kb
    transcript ENSMUST00000107912 Ensembl | MGI Sequence Detail 1839 Not Applicable  
    polypeptide ENSMUSP00000103545 Ensembl | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      cDNA 138
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24047, MGI:103179, MGI:2141876
    References
    more
    • Summaries
      All 269
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 21
      Phenotypes 165
    • Earliest
      J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
    • Latest
      J:338239 van Wouw SAE, et al., Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages. J Lipid Res. 2023 Feb;64(2):100325
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory