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Igfbp7 Gene Detail
Summary
  • Symbol
    Igfbp7
  • Name
    insulin-like growth factor binding protein 7
  • Synonyms
    AGM, Fstl2, mac25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352480
    NCBI Gene: 29817
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:77497092-77555892 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 41.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1911 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352480
 protein coding gene Chr5:77497087-77555892 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029659
 protein coding gene Chr5:77627356-77698237 (-)
A/J MGP_AJ_G0029627
 protein coding gene Chr5:74621351-74680681 (-)
AKR/J MGP_AKRJ_G0029575
 protein coding gene Chr5:77081031-77140547 (-)
BALB/cJ MGP_BALBcJ_G0029636
 protein coding gene Chr5:75362098-75421002 (-)
C3H/HeJ MGP_C3HHeJ_G0029359
 protein coding gene Chr5:77435963-77499340 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030090
 protein coding gene Chr5:80711395-80781504 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027330
 protein coding gene Chr5:70355379-70415850 (-)
CAST/EiJ MGP_CASTEiJ_G0028767
 protein coding gene Chr5:76659547-76721797 (-)
CBA/J MGP_CBAJ_G0029328
 protein coding gene Chr5:83385414-83448941 (-)
DBA/2J MGP_DBA2J_G0029473
 protein coding gene Chr5:74680454-74742302 (-)
FVB/NJ MGP_FVBNJ_G0029434
 protein coding gene Chr5:73889756-73949704 (-)
LP/J MGP_LPJ_G0029560
 protein coding gene Chr5:78025804-78097142 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029462
 protein coding gene Chr5:86483309-86546725 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030123
 protein coding gene Chr5:76626876-76687782 (-)
PWK/PhJ MGP_PWKPhJ_G0028490
 protein coding gene Chr5:73704343-73764100 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028325
 protein coding gene Chr5:75998211-76075627 (-)
WSB/EiJ MGP_WSBEiJ_G0028847
 protein coding gene Chr5:76947548-77014850 (-)



Homology
more
  • Human Ortholog
    IGFBP7, insulin like growth factor binding protein 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGFBP7, insulin like growth factor binding protein 7
  • Synonyms
    AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF
  • Links
    NCBI Gene ID: 3490
    neXtProt AC: NX_Q16270
    UniProt: Q16270

  • Chr Location
    4q12; chr4:57030773-57110385 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit retarded mammary gland developmental in virgin and adult females, reduced mammary gland size and alveolar density during pregnancy, precocious involution in lactating mammary glands, and abnormal milk composition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    920
  • Tissues
    131
  • cDNA Data
    17
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 29817 NCBI Gene Model | MGI Sequence Detail 58801 C57BL/6J ±  kb
    transcript NM_001159518 RefSeq | MGI Sequence Detail 1208 C57BL/6  
    polypeptide Q61581 UniProt | EBI | MGI Sequence Detail 281 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008953 insulin-like growth factor-binding protein 7
      (term hierarchy)
    • InterPro Domains
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR000867 Insulin-like growth factor-binding protein, IGFBP
      IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
      IPR002350 Kazal domain
      IPR036058 Kazal domain superfamily
    • GlyGen
      Q61581 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 19
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37071, MGI:108035
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 24
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory