About   Help   FAQ
Fscn1 Gene Detail
Summary
  • Symbol
    Fscn1
  • Name
    fascin actin-bundling protein 1
  • Synonyms
    Fan1, fascin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352745
    NCBI Gene: 14086
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:142946110-142958944 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 81.84 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    419 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352745
 protein coding gene Chr5:142946098-142958944 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030320
 protein coding gene Chr5:148260458-148275004 (+)
A/J MGP_AJ_G0030289
 protein coding gene Chr5:141896057-141909556 (+)
AKR/J MGP_AKRJ_G0030221
 protein coding gene Chr5:146321233-146334867 (+)
BALB/cJ MGP_BALBcJ_G0030306
 protein coding gene Chr5:143142204-143154986 (+)
C3H/HeJ MGP_C3HHeJ_G0030017
 protein coding gene Chr5:147143621-147156587 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030751
 protein coding gene Chr5:153665851-153682780 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027969
 protein coding gene Chr5:135695577-135709503 (+)
CAST/EiJ MGP_CASTEiJ_G0029422
 protein coding gene Chr5:146628499-146648989 (+)
CBA/J MGP_CBAJ_G0029987
 protein coding gene Chr5:159978184-159990803 (+)
DBA/2J MGP_DBA2J_G0030137
 protein coding gene Chr5:141658060-141670784 (+)
FVB/NJ MGP_FVBNJ_G0030092
 protein coding gene Chr5:140866746-140879408 (+)
LP/J MGP_LPJ_G0030223
 protein coding gene Chr5:148862648-148875442 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030123
 protein coding gene Chr5:162445878-162459141 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030791
 protein coding gene Chr5:146184455-146197207 (+)
PWK/PhJ MGP_PWKPhJ_G0029137
 protein coding gene Chr5:140746484-140759892 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028973
 protein coding gene Chr5:143932212-143959517 (+)
WSB/EiJ MGP_WSBEiJ_G0029496
 protein coding gene Chr5:146979096-146993599 (+)



Homology
more
  • Human Ortholog
    FSCN1, fascin actin-bundling protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FSCN1, fascin actin-bundling protein 1
  • Synonyms
    FAN1, HSN, p55, SNL
  • Links
    NCBI Gene ID: 6624
    neXtProt AC: NX_Q16658
    UniProt: Q16658

  • Chr Location
    7p22.1; chr7:5592816-5606655 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele show partial neonatal lethality, smaller size, enlarged lateral ventricles, abnormal anterior commissure pars posterior morphology, impaired migration of mature dendritic cells, and hypopigmentation due to migration and cell cycle defects in melanoblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    85
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1059
  • Tissues
    228
  • cDNA Data
    18
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14086 NCBI Gene Model | MGI Sequence Detail 12835 C57BL/6J ±  kb
    transcript NM_007984 RefSeq | MGI Sequence Detail 2667 ZRU/MplStud  
    polypeptide Q61553 UniProt | EBI | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 18
      Primer pair 3
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-36269, MGI:107693, MGI:2140957
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 13
      Gene Ontology 17
      Phenotypes 22
    • Earliest
      J:25101 Edwards RA, et al., Cloning and expression of a murine fascin homolog from mouse brain. J Biol Chem. 1995 May 5;270(18):10764-70
    • Latest
      J:347974 Zhou B, et al., Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos. Dev Cell. 2024 Apr 15;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory