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Iqgap1 Gene Detail
Summary
  • Symbol
    Iqgap1
  • Name
    IQ motif containing GTPase activating protein 1
  • Synonyms
    D7Ertd237e, D7Ertd257e, mKIAA0051
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352757
    NCBI Gene: 29875
  • Alliance
    gene page
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80361331-80453288 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2587 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352757
 protein coding gene Chr7:80361331-80475722 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032418
 protein coding gene Chr7:82700960-82828469 (-)
A/J MGP_AJ_G0032397
 protein coding gene Chr7:80766057-80884120 (-)
AKR/J MGP_AKRJ_G0032333
 protein coding gene Chr7:82537050-82653617 (-)
BALB/cJ MGP_BALBcJ_G0032409
 protein coding gene Chr7:80439401-80556025 (-)
C3H/HeJ MGP_C3HHeJ_G0032122
 protein coding gene Chr7:83161333-83289709 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032901
 protein coding gene Chr7:85937836-86068138 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029909
 protein coding gene Chr7:83279954-83395278 (-)
CAST/EiJ MGP_CASTEiJ_G0031450
 protein coding gene Chr7:74043309-74180962 (-)
CBA/J MGP_CBAJ_G0032088
 protein coding gene Chr7:88795731-88932478 (-)
DBA/2J MGP_DBA2J_G0032243
 protein coding gene Chr7:79319653-79433208 (-)
FVB/NJ MGP_FVBNJ_G0032198
 protein coding gene Chr7:79245563-79365593 (-)
LP/J MGP_LPJ_G0032324
 protein coding gene Chr7:83942818-84063885 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032235
 protein coding gene Chr7:88934988-89063968 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032919
 protein coding gene Chr7:81957173-82083221 (-)
PWK/PhJ MGP_PWKPhJ_G0031170
 protein coding gene Chr7:72499755-72633382 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031011
 protein coding gene Chr7:68954268-69101968 (-)
WSB/EiJ MGP_WSBEiJ_G0031568
 protein coding gene Chr7:82317490-82447962 (-)



Homology
more
  • Human Ortholog
    IQGAP1, IQ motif containing GTPase activating protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IQGAP1, IQ motif containing GTPase activating protein 1
  • Synonyms
    HUMORFA01, p195, SAR1
  • Links
    NCBI Gene ID: 8826
    neXtProt AC: NX_P46940
    UniProt: P46940

  • Chr Location
    15q26.1; chr15:90388242-90502239 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null allele exhibit a late-onset gastric hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    128
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    927
  • Tissues
    110
  • cDNA Data
    308
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 29875 NCBI Gene Model | MGI Sequence Detail 91958 C57BL/6J ±  kb
    transcript NM_016721 RefSeq | MGI Sequence Detail 7377 ZRU/MplStud  
    polypeptide Q9JKF1 UniProt | EBI | MGI Sequence Detail 1657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 317
      cDNA 312
      Primer pair 5

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1098558, MGI:1098580, MGI:2141849
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 9
      Gene Ontology 19
      Phenotypes 60
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:350816 He Y, et al., Hippocampal circAnk3 Deficiency Causes Anxiety-like Behaviors and Social Deficits by Regulating the miR-7080-3p/IQGAP1 Pathway in Mice. Biol Psychiatry. 2024 May 1;95(9):896-908
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory