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Ulk2 Gene Detail
Summary
  • Symbol
    Ulk2
  • Name
    unc-51 like kinase 2
  • Synonyms
    A830085I22Rik, mKIAA0623, Unc51.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352758
    NCBI Gene: 29869
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61666475-61745899 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1752 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352758
 protein coding gene Chr11:61666424-61750754 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018447
 protein coding gene Chr11:61752446-61840573 (-)
A/J MGP_AJ_G0018416
 protein coding gene Chr11:59480650-59574429 (-)
AKR/J MGP_AKRJ_G0018386
 protein coding gene Chr11:61317302-61400836 (-)
BALB/cJ MGP_BALBcJ_G0018387
 protein coding gene Chr11:59779410-59859268 (-)
C3H/HeJ MGP_C3HHeJ_G0018200
 protein coding gene Chr11:61306425-61392293 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018839
 protein coding gene Chr11:63712741-63807464 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016485
 protein coding gene Chr11:56592182-56678034 (-)
CAST/EiJ MGP_CASTEiJ_G0017757
 protein coding gene Chr11:61409991-61504509 (-)
CBA/J MGP_CBAJ_G0018174
 protein coding gene Chr11:66482741-66579554 (-)
DBA/2J MGP_DBA2J_G0018283
 protein coding gene Chr11:59044799-59126359 (-)
FVB/NJ MGP_FVBNJ_G0018274
 protein coding gene Chr11:58729963-58810674 (-)
LP/J MGP_LPJ_G0018356
 protein coding gene Chr11:62324851-62406047 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018298
 protein coding gene Chr11:67467880-67580131 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018880
 protein coding gene Chr11:61465178-61545684 (-)
PWK/PhJ MGP_PWKPhJ_G0017530
 protein coding gene Chr11:59652515-59734461 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017320
 protein coding gene Chr11:61286983-61370695 (-)
WSB/EiJ MGP_WSBEiJ_G0017809
 protein coding gene Chr11:61065409-61151469 (-)



Homology
more
  • Human Ortholog
    ULK2, unc-51 like autophagy activating kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ULK2, unc-51 like autophagy activating kinase 2
  • Synonyms
    ATG1B, Unc51.2
  • Links
    NCBI Gene ID: 9706
    neXtProt AC: NX_Q8IYT8
    UniProt: Q8IYT8

  • Chr Location
    17p11.2; chr17:19770829-19867936 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in an increased anxiety-like response in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    97
  • cDNA Data
    16
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004798 Ensembl Gene Model | MGI Sequence Detail 79425 C57BL/6J ±  kb
transcript ENSMUST00000004920 Ensembl | MGI Sequence Detail 5743 Not Applicable  
polypeptide ENSMUSP00000004920 Ensembl | MGI Sequence Detail 1037 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017078 serine/threonine-protein kinase ULK2
    (term hierarchy)
  • EC
    2.7.11.1
  • InterPro Domains
    IPR048941 ATG1-like, MIT domain 2
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
    IPR045269 Serine/threonine-protein kinase Atg1-like
    IPR022708 Serine/threonine-protein kinase Atg1-like, tMIT domain
    IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2
  • GlyGen
    Q9QY01 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)
Molecular
Reagents
less
  • All nucleic 19
    cDNA 17
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:2144370, MGI:2444180
References
more
  • Summaries
    All 64
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 23
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345168 Kremer LS, et al., A role for BCL2L13 and autophagy in germline purifying selection of mtDNA. PLoS Genet. 2023 Jan;19(1):e1010573
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory