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Eif2ak2 Gene Detail
Summary
  • Symbol
    Eif2ak2
  • Name
    eukaryotic translation initiation factor 2-alpha kinase 2
  • Synonyms
    2310047A08Rik, 4732414G15Rik, dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, IFN-induced and double-stranded RNA-activated kinase, IFN- type I-induced and dsRNA-activated kinase, Pkr, Prkr, Tik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353449
    NCBI Gene: 19106
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:79159993-79190002 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 49.56 cM, cytoband E2
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    834 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353449
 protein coding gene Chr17:79157933-79190002 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024043
 protein coding gene Chr17:81687566-81720040 (-)
A/J MGP_AJ_G0024000
 protein coding gene Chr17:79188990-79219266 (-)
AKR/J MGP_AKRJ_G0023969
 protein coding gene Chr17:80388515-80422618 (-)
BALB/cJ MGP_BALBcJ_G0024002
 protein coding gene Chr17:79052159-79088178 (-)
C3H/HeJ MGP_C3HHeJ_G0023766
 protein coding gene Chr17:81293996-81325784 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024446
 protein coding gene Chr17:84669649-84701328 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021889
 protein coding gene Chr17:74582280-74612575 (-)
CAST/EiJ MGP_CASTEiJ_G0023246
 protein coding gene Chr17:81898163-81931429 (-)
CBA/J MGP_CBAJ_G0023740
 protein coding gene Chr17:88200418-88232686 (-)
DBA/2J MGP_DBA2J_G0023869
 protein coding gene Chr17:77706711-77736584 (-)
FVB/NJ MGP_FVBNJ_G0023835
 protein coding gene Chr17:77224710-77255155 (-)
LP/J MGP_LPJ_G0023952
 protein coding gene Chr17:82536843-82568752 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023863
 protein coding gene Chr17:88320293-88355759 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024491
 protein coding gene Chr17:80866645-80899978 (-)
PWK/PhJ MGP_PWKPhJ_G0022992
 protein coding gene Chr17:77201732-77233621 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022803
 protein coding gene Chr17:77659700-77687191 (-)
WSB/EiJ MGP_WSBEiJ_G0023313
 protein coding gene Chr17:81682597-81715588 (-)



Homology
more
  • Human Ortholog
    EIF2AK2, eukaryotic translation initiation factor 2 alpha kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF2AK2, eukaryotic translation initiation factor 2 alpha kinase 2
  • Synonyms
    DYT33, EIF2AK1, LEUDEN, PKR, PPP1R83, PRKR
  • Links
    NCBI Gene ID: 5610
    neXtProt AC: NX_P19525
    UniProt: P19525

  • Chr Location
    2p22.2; chr2:37099210-37157522 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human EIF2AK2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 5 genetic backgrounds
    13 phenotypes from multigenic genotypes
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display altered susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    91
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    39
  • cDNA Data
    38
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024079 Ensembl Gene Model | MGI Sequence Detail 30010 C57BL/6J ±  kb
    transcript ENSMUST00000024884 Ensembl | MGI Sequence Detail 4313 Not Applicable  
    polypeptide ENSMUSP00000024884 Ensembl | MGI Sequence Detail 515 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 6
      cDNA 38
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13612, MGD-MRK-15108, MGI:1924009, MGI:2146878, MGI:2146919, MGI:97761, MGI:98750
    References
    more
    • Summaries
      All 192
      Developmental Gene Expression 6
      Gene Ontology 23
      Phenotypes 93
    • Earliest
      J:43390 Icely PL, et al., TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J Biol Chem. 1991 Aug 25;266(24):16073-7
    • Latest
      J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory