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Slc25a4 Gene Detail
Summary
  • Symbol
    Slc25a4
  • Name
    solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
  • Synonyms
    adenine nucleotide translocase-1, Ant1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353495
    NCBI Gene: 11739
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:46660205-46664099 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 26.22 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353495
 protein coding gene Chr8:46659834-46664321 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033586
 protein coding gene Chr8:45302685-45307172 (-)
A/J MGP_AJ_G0033568
 protein coding gene Chr8:43541852-43546339 (-)
AKR/J MGP_AKRJ_G0033493
 protein coding gene Chr8:44826605-44831092 (-)
BALB/cJ MGP_BALBcJ_G0033565
 protein coding gene Chr8:43726965-43731452 (-)
C3H/HeJ MGP_C3HHeJ_G0033274
 protein coding gene Chr8:45362973-45367460 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034081
 protein coding gene Chr8:47005541-47010028 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031030
 protein coding gene Chr8:39815228-39819867 (-)
CAST/EiJ MGP_CASTEiJ_G0032600
 protein coding gene Chr8:44802718-44807031 (-)
CBA/J MGP_CBAJ_G0033253
 protein coding gene Chr8:48910377-48914864 (-)
DBA/2J MGP_DBA2J_G0033406
 protein coding gene Chr8:43355506-43359993 (-)
FVB/NJ MGP_FVBNJ_G0033347
 protein coding gene Chr8:42847310-42851797 (-)
LP/J MGP_LPJ_G0033494
 protein coding gene Chr8:45306589-45311076 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033392
 protein coding gene Chr8:48976531-48981018 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034099
 protein coding gene Chr8:44990894-44995381 (-)
PWK/PhJ MGP_PWKPhJ_G0032308
 protein coding gene Chr8:42881208-42885724 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032144
 protein coding gene Chr8:44147838-44152336 (-)
WSB/EiJ MGP_WSBEiJ_G0032716
 protein coding gene Chr8:45246605-45251090 (-)



Homology
more
  • Human Ortholog
    SLC25A4, solute carrier family 25 member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A4, solute carrier family 25 member 4
  • Synonyms
    AAC1, ANT, ANT 1, ANT1, MTDPS12, MTDPS12A, PEO2, PEO3, PEOA2, T1
  • Links
    NCBI Gene ID: 291
    neXtProt AC: NX_P12235
    UniProt: P12235

  • Chr Location
    4q35.1; chr4:185143266-185150382 (+)  GRCh38
Human Diseases
more
  • Diseases
    7 with human SLC25A4 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a defect in mitochondrial energy metabolism and develop mitochondrial myopathy and hypertrophic cardiomyopathy, metabolic acidosis, and a severe exercise intolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    526
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11739 NCBI Gene Model | MGI Sequence Detail 3895 C57BL/6J ±  kb
    transcript NM_007450 RefSeq | MGI Sequence Detail 1332 ZRU/MplStud  
    polypeptide P48962 UniProt | EBI | MGI Sequence Detail 298 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 536
      Genomic 2
      cDNA 527
      Primer pair 6
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16246, MGI:2142690, MGI:99472
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 8
      Gene Ontology 15
      Phenotypes 27
    • Earliest
      J:41737 Cozens AL, et al., DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. J Mol Biol. 1989 20;206(2):261-80
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory