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Ddx25 Gene Detail
Summary
  • Symbol
    Ddx25
  • Name
    DEAD box helicase 25
  • Synonyms
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 25, GRTH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353582
    NCBI Gene: 30959
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:35453144-35469766 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.31 cM, cytoband A3-A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    537 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353582
 protein coding gene Chr9:35447943-35469824 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034536
 protein coding gene Chr9:33351103-33373938 (-)
A/J MGP_AJ_G0034514
 protein coding gene Chr9:32482648-32504523 (-)
AKR/J MGP_AKRJ_G0034440
 protein coding gene Chr9:33217183-33239071 (-)
BALB/cJ MGP_BALBcJ_G0034505
 protein coding gene Chr9:32400957-32422852 (-)
C3H/HeJ MGP_C3HHeJ_G0034217
 protein coding gene Chr9:33550471-33572359 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035026
 protein coding gene Chr9:34466089-34487982 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031956
 protein coding gene Chr9:31169942-31192130 (-)
CAST/EiJ MGP_CASTEiJ_G0033540
 protein coding gene Chr9:33456596-33478348 (-)
CBA/J MGP_CBAJ_G0034191
 protein coding gene Chr9:35618151-35644484 (-)
DBA/2J MGP_DBA2J_G0034348
 protein coding gene Chr9:32466270-32488169 (-)
FVB/NJ MGP_FVBNJ_G0034291
 protein coding gene Chr9:31883479-31905360 (-)
LP/J MGP_LPJ_G0034434
 protein coding gene Chr9:33594614-33616385 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034335
 protein coding gene Chr9:37186474-37208367 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035046
 protein coding gene Chr9:33164423-33186182 (-)
PWK/PhJ MGP_PWKPhJ_G0033245
 protein coding gene Chr9:32451261-32473284 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033080
 protein coding gene Chr9:33313735-33336335 (-)
WSB/EiJ MGP_WSBEiJ_G0033655
 protein coding gene Chr9:32937872-32959762 (-)



Homology
more
  • Human Ortholog
    DDX25, DEAD-box helicase 25
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX25, DEAD-box helicase 25
  • Synonyms
    GRTH
  • Links
    NCBI Gene ID: 29118
    neXtProt AC: NX_Q9UHL0
    UniProt: Q9UHL0

  • Chr Location
    11q24.2; chr11:125903328-125943702 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display male infertility, arrest of spermatogenesis at step 8, abnormal Leydig cells, and increased germ cell apoptosis in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    3
  • cDNA Data
    46
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30959 NCBI Gene Model | MGI Sequence Detail 16623 C57BL/6J ±  kb
    transcript NM_013932 RefSeq | MGI Sequence Detail 1675 C57BL/6  
    polypeptide Q9QY15 UniProt | EBI | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 46

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143278
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:59130 Tang PZ, et al., A novel gonadotropin-regulated testicular RNA helicase. A new member of the dead-box family. J Biol Chem. 1999 Dec 31;274(53):37932-40
    • Latest
      J:337868 Anbazhagan R, et al., miRNA Expression Profiles of Mouse Round Spermatids in GRTH/DDX25-Mediated Spermiogenesis: mRNA-miRNA Network Analysis. Cells. 2023 Feb 27;12(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory