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Tmprss2 Gene Detail
Summary
  • Symbol
    Tmprss2
  • Name
    transmembrane protease, serine 2
  • Synonyms
    D16Ertd61e, epitheliasin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354381
    NCBI Gene: 50528
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:97365882-97412395 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 57.53 cM, cytoband C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1151 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354381
 protein coding gene Chr16:97365882-97460741 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023092
 protein coding gene Chr16:99005707-99060184 (-)
A/J MGP_AJ_G0023060
 protein coding gene Chr16:94336958-94383722 (-)
AKR/J MGP_AKRJ_G0023030
 protein coding gene Chr16:97235782-97292012 (-)
BALB/cJ MGP_BALBcJ_G0023062
 protein coding gene Chr16:94883700-94931566 (-)
C3H/HeJ MGP_C3HHeJ_G0022823
 protein coding gene Chr16:97762860-97815126 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023509
 protein coding gene Chr16:102100255-102154023 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0022343
 protein coding gene Chr16:98576922-98624091 (-)
CBA/J MGP_CBAJ_G0022792
 protein coding gene Chr16:106540158-106596263 (-)
DBA/2J MGP_DBA2J_G0022926
 protein coding gene Chr16:94197206-94244565 (-)
FVB/NJ MGP_FVBNJ_G0022900
 protein coding gene Chr16:93357253-93404999 (-)
LP/J MGP_LPJ_G0022996
 protein coding gene Chr16:98654874-98704482 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022921
 protein coding gene Chr16:110678508-110735567 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023527
 protein coding gene Chr16:97789813-97834707 (-)
PWK/PhJ MGP_PWKPhJ_G0022087
 protein coding gene Chr16:94526016-94574976 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021917
 protein coding gene Chr16:97285195-97335352 (-)
WSB/EiJ MGP_WSBEiJ_G0022393
 protein coding gene Chr16:98058105-98106129 (-)



Homology
more
  • Human Ortholog
    TMPRSS2, transmembrane serine protease 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMPRSS2, transmembrane serine protease 2
  • Synonyms
    PRSS10
  • Links
    NCBI Gene ID: 7113
    neXtProt AC: NX_O15393
    UniProt: O15393

  • Chr Location
    21q22.3; chr21:41464300-41531116 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 6 genetic backgrounds
    13 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene appear normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1201
  • Tissues
    268
  • cDNA Data
    167
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000385 Ensembl Gene Model | MGI Sequence Detail 46514 C57BL/6J ±  kb
    transcript ENSMUST00000000395 Ensembl | MGI Sequence Detail 3161 Not Applicable  
    polypeptide ENSMUSP00000000395 Ensembl | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 185
      Genomic 1
      cDNA 169
      Primer pair 11
      Other 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1098555
    References
    more
    • Summaries
      All 116
      Developmental Gene Expression 15
      Gene Ontology 7
      Phenotypes 51
    • Earliest
      J:60563 Jacquinet E, et al., Cloning, genomic organization, chromosomal assignment and expression of a novel mosaic serine proteinase: epitheliasin. FEBS Lett. 2000 Feb 18;468(1):93-100
    • Latest
      J:352136 Liu H, et al., Establishment and characterization of an hACE2/hTMPRSS2 knock-in mouse model to study SARS-CoV-2. Front Immunol. 2024;15:1428711
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory