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Slc25a13 Gene Detail
Summary
  • Symbol
    Slc25a13
  • Name
    solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
  • Synonyms
    citrin, Ctrn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354721
    NCBI Gene: 50799
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:6041218-6217173 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 2.30 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5463 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354721
 protein coding gene Chr6:6041218-6217304 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030438
 protein coding gene Chr6:2920136-3107649 (-)
A/J MGP_AJ_G0030411
 protein coding gene Chr6:2797867-2981479 (-)
AKR/J MGP_AKRJ_G0030338
 protein coding gene Chr6:2870572-3057397 (-)
BALB/cJ MGP_BALBcJ_G0030420
 protein coding gene Chr6:2767691-2944003 (-)
C3H/HeJ MGP_C3HHeJ_G0030134
 protein coding gene Chr6:2858074-3046816 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030875
 protein coding gene Chr6:2981801-3173243 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028086
 protein coding gene Chr6:2474986-2610491 (-)
CAST/EiJ MGP_CASTEiJ_G0029535
 protein coding gene Chr6:2841724-3039009 (-)
CBA/J MGP_CBAJ_G0030112
 protein coding gene Chr6:3138919-3325202 (-)
DBA/2J MGP_DBA2J_G0030256
 protein coding gene Chr6:2753057-2935859 (-)
FVB/NJ MGP_FVBNJ_G0030210
 protein coding gene Chr6:2734610-2914647 (-)
LP/J MGP_LPJ_G0030343
 protein coding gene Chr6:2862904-3046108 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030246
 protein coding gene Chr6:3151968-3335141 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030905
 protein coding gene Chr6:2835455-3024625 (-)
PWK/PhJ MGP_PWKPhJ_G0029250
 protein coding gene Chr6:2701152-2881265 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029086
 protein coding gene Chr6:2889266-3070757 (-)
WSB/EiJ MGP_WSBEiJ_G0029612
 protein coding gene Chr6:2836712-3017842 (-)



Homology
more
  • Human Ortholog
    SLC25A13, solute carrier family 25 member 13
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A13, solute carrier family 25 member 13
  • Synonyms
    ARALAR2, CITRIN, CTLN2, NICCD
  • Links
    NCBI Gene ID: 10165
    neXtProt AC: NX_Q9UJS0
    UniProt: Q9UJS0

  • Chr Location
    7q21.3; chr7:96120220-96322147 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SLC25A13 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene appear normal, healthy and fertile, although they have a number of metabolic defects, but the spontaneous hyperspin deletion spanning from intron 3 to exon 17 also eliminates a modifier of Dlx5 causing a recessive vestibular and mortality phenotype
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    965
  • Tissues
    73
  • cDNA Data
    16
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015112 Ensembl Gene Model | MGI Sequence Detail 175956 C57BL/6J ±  kb
    transcript ENSMUST00000015256 Ensembl | MGI Sequence Detail 3067 Not Applicable  
    polypeptide ENSMUSP00000015256 Ensembl | MGI Sequence Detail 676 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 16
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141468
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 10
      Phenotypes 22
    • Earliest
      J:59976 Sinasac DS, et al., Genomic structure of the adult-onset type II citrullinemia gene, SLC25A13, and cloning and expression of its mouse homologue. Genomics. 1999 Dec 1;62(2):289-92
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory