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Uchl3 Gene Detail
Summary
  • Symbol
    Uchl3
  • Name
    ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355274
    NCBI Gene: 50933
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:101891403-101933561 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 50.90 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1201 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355274
 protein coding gene Chr14:101891387-101933561 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021623
 protein coding gene Chr14:98083779-98129977 (+)
A/J MGP_AJ_G0021581
 protein coding gene Chr14:94880387-94923009 (+)
AKR/J MGP_AKRJ_G0021557
 protein coding gene Chr14:97686199-97728270 (+)
BALB/cJ MGP_BALBcJ_G0021587
 protein coding gene Chr14:95216068-95259295 (+)
C3H/HeJ MGP_C3HHeJ_G0021365
 protein coding gene Chr14:97595645-97639227 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022027
 protein coding gene Chr14:102037941-102086827 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019567
 protein coding gene Chr14:91820973-91863705 (+)
CAST/EiJ MGP_CASTEiJ_G0020882
 protein coding gene Chr14:94919204-94966072 (+)
CBA/J MGP_CBAJ_G0021333
 protein coding gene Chr14:105792113-105843942 (+)
DBA/2J MGP_DBA2J_G0021457
 protein coding gene Chr14:94365501-94408280 (+)
FVB/NJ MGP_FVBNJ_G0021434
 protein coding gene Chr14:93354500-93397715 (+)
LP/J MGP_LPJ_G0021525
 protein coding gene Chr14:98869507-98930838 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021461
 protein coding gene Chr14:108526147-108574042 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022050
 protein coding gene Chr14:97201359-97246401 (+)
PWK/PhJ MGP_PWKPhJ_G0020625
 protein coding gene Chr14:91373348-91416393 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020463
 protein coding gene Chr14:93232920-93279051 (+)
WSB/EiJ MGP_WSBEiJ_G0020935
 protein coding gene Chr14:97854886-97900127 (+)



Homology
more
  • Human Ortholog
    UCHL3, ubiquitin C-terminal hydrolase L3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UCHL3, ubiquitin C-terminal hydrolase L3
  • Synonyms
    UCH-L3
  • Links
    NCBI Gene ID: 7347
    neXtProt AC: NX_P15374
    UniProt: P15374

  • Chr Location
    13q22.2; chr13:75549483-75606020 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null animals show degeneration in dorsal root ganglia. Mice display postnatal progressive retinal degeneration and muscular degeneration. In combination with a knockout of ubiquitin C-terminal hydrolase L1, neurological effects of each are accelerated, mice are dysphagic and die younger.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    23
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    25
  • cDNA Data
    40
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022111 Ensembl Gene Model | MGI Sequence Detail 42159 C57BL/6J ±  kb
    transcript ENSMUST00000226340 Ensembl | MGI Sequence Detail 935 Not Applicable  
    polypeptide ENSMUSP00000154032 Ensembl | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000017025 ubiquitin carboxyl-terminal hydrolase isozyme L3
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase
      IPR036959 Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 40
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:61093 Kurihara LJ, et al., Expression and functional analysis of Uch-L3 during mouse development. Mol Cell Biol. 2000 Apr;20(7):2498-504
    • Latest
      J:282558 Collin GB, et al., Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells. 2020 Apr 10;9(4):931
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory