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Nono Gene Detail
Summary
  • Symbol
    Nono
  • Name
    non-POU-domain-containing, octamer binding protein
  • Synonyms
    P54NRB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855692
    NCBI Gene: 53610
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:100473295-100492193 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 44.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    384 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1855692
 protein coding gene ChrX:100472924-100492197 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035961
 protein coding gene ChrX:97941643-97961559 (+)
A/J MGP_AJ_G0035946
 protein coding gene ChrX:97940425-97959718 (+)
AKR/J MGP_AKRJ_G0035862
 protein coding gene ChrX:100755815-100778051 (+)
BALB/cJ MGP_BALBcJ_G0035929
 protein coding gene ChrX:96689368-96709951 (+)
C3H/HeJ MGP_C3HHeJ_G0035638
 protein coding gene ChrX:98348100-98368199 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036458
 protein coding gene ChrX:100844060-100865239 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033288
 protein coding gene ChrX:95689431-95707965 (+)
CAST/EiJ MGP_CASTEiJ_G0034925
 protein coding gene ChrX:82650600-82672591 (+)
CBA/J MGP_CBAJ_G0035613
 protein coding gene ChrX:103969029-103994562 (+)
DBA/2J MGP_DBA2J_G0035767
 protein coding gene ChrX:97150643-97169945 (+)
FVB/NJ MGP_FVBNJ_G0035705
 protein coding gene ChrX:96533982-96553331 (+)
LP/J MGP_LPJ_G0035857
 protein coding gene ChrX:98896297-98917915 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035740
 protein coding gene ChrX:108516971-108539141 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036485
 protein coding gene ChrX:97638111-97658636 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    NONO, non-POU domain containing octamer binding
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NONO, non-POU domain containing octamer binding
  • Synonyms
    MRXS34, NMT55, NRB54, P54, P54NRB, PPP1R114
  • Links
    NCBI Gene ID: 4841
    neXtProt AC: NX_Q15233
    UniProt: Q15233

  • Chr Location
    Xq13.1; chrX:71254814-71301522 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human NONO associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 5 alleles in 4 genetic backgrounds
    36 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice carrying a gene trap trap allele show shortening of the circadian period under constant dark conditions. Chimeras for some other gene trap alleles may display gastrulation defects. Hemizygous KO in males causes cardiac fibrosis and results in decreased body weight and increased mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    45
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    34
  • cDNA Data
    19
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53610 NCBI Gene Model | MGI Sequence Detail 18899 C57BL/6J ±  kb
    transcript NM_001426220 RefSeq | MGI Sequence Detail 2451 C57BL/6  
    polypeptide Q99K48 UniProt | EBI | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 19
      Primer pair 2
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2139550, MGI:3034758
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 9
      Gene Ontology 16
      Phenotypes 21
    • Earliest
      J:24184 Yang YS, et al., NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. Mol Cell Biol. 1993 Sep;13(9):5593-603
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory