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Isg15 Gene Detail
Summary
  • Symbol
    Isg15
  • Name
    ISG15 ubiquitin-like modifier
  • Synonyms
    G1p2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855694
    NCBI Gene: 100038882
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:156283912-156285253 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 88.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    221 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1855694
 protein coding gene Chr4:156283881-156285275 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029248
 protein coding gene Chr4:160569247-160570639 (-)
A/J MGP_AJ_G0029213
 protein coding gene Chr4:153804423-153805823 (-)
AKR/J MGP_AKRJ_G0029161
 protein coding gene Chr4:157993922-157995314 (-)
BALB/cJ MGP_BALBcJ_G0029229
 protein coding gene Chr4:154280470-154281871 (-)
C3H/HeJ MGP_C3HHeJ_G0028950
 protein coding gene Chr4:158566040-158567328 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029678
 protein coding gene Chr4:166270275-166271670 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026922
 protein coding gene Chr4:146080380-146081810 (-)
CAST/EiJ MGP_CASTEiJ_G0028362
 protein coding gene Chr4:155986457-155987857 (-)
CBA/J MGP_CBAJ_G0028912
 protein coding gene Chr4:171314994-171316388 (-)
DBA/2J MGP_DBA2J_G0029061
 protein coding gene Chr4:153823880-153825274 (-)
FVB/NJ MGP_FVBNJ_G0029024
 protein coding gene Chr4:153071301-153074911 (-)
LP/J MGP_LPJ_G0029151
 protein coding gene Chr4:160517933-160519325 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029051
 protein coding gene Chr4:174086982-174088935 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029710
 protein coding gene Chr4:158629996-158631390 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0027917
 protein coding gene Chr4:152877509-152878880 (-)
WSB/EiJ MGP_WSBEiJ_G0028442
 protein coding gene Chr4:158806770-158808169 (-)



Homology
more
  • Human Ortholog
    ISG15, ISG15 ubiquitin like modifier
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ISG15, ISG15 ubiquitin like modifier
  • Synonyms
    G1P2, hUCRP, IFI15, IMD38, IP17, UCRP
  • Links
    NCBI Gene ID: 9636
    neXtProt AC: NX_P05161
    UniProt: P05161

  • Chr Location
    1p36.33
Human Diseases
more
  • Diseases
    1 with human ISG15 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile and do not display immunological abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    15
  • cDNA Data
    4
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035692 Ensembl Gene Model | MGI Sequence Detail 1342 C57BL/6J ±  kb
    transcript ENSMUST00000085425 Ensembl | MGI Sequence Detail 703 Not Applicable  
    polypeptide ENSMUSP00000082548 Ensembl | MGI Sequence Detail 161 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 5
      Primer pair 2
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:3809535
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 14
      Gene Ontology 17
      Phenotypes 35
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347095 Homma H, et al., Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Commun Biol. 2024 Apr 9;7(1):413
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory