Tyr<c-ch> Spontaneous Allele Detail MGI Mouse (MGI:1855977)

Tyr^c-ch
Spontaneous Allele Detail

Summary

Symbol:	Tyr^c-ch
Name:	tyrosinase; chinchilla
MGI ID:	MGI:1855977
Synonyms:	c^ch, c^r
Gene:	Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
Alliance:	Tyr^c-ch page

Tyr^c/Tyr^c and Tyr^c/Tyr^c-ch Oca2^p/ Oca2^p

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

fancier's stock

Mutation
description

Allele Type:		Spontaneous
Mutation:		Single point mutation
		Mutation details: The mutation in the chinchilla allele was found to be a G-to-A point mutation that results in an amino acid change at position 482 or 464 from alanine to threonine (p.A482T for pre-protein, p.A464T for mature protein). (J:19279)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	7 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tyr^c-ch

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 79 strains available Cell Lines: 0 lines available
Carrying any Tyr Mutation:	379 strains or lines available

References

Original:	J:14850 Feldman HW, A fourth allelomorph in the albino series in mice. Am Naturalist. 1922;56:573-574
All:	49 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24