Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol: Leprdb Name: leptin receptor; diabetes MGI ID: MGI:1856009 Synonyms: db, db/db, Lepdb, Lepr-, leprdb, Leprdb-1J Gene: Lepr  Location: Chr4:101574601-101672549 bp, + strand  Genetic Position: Chr4, 46.96 cM Alliance: Leprdb page

Increased beta cell mass in Leprdb/Leprdb mice and Leprdb/Leprdb Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 mice Show the 2 phenotype image(s) involving this allele.

Strain of Origin:

C57BLKS/J

Allele Type:    Spontaneous Mutation:    Single point mutation   Mutation details: An intronic G-to-T transversion in this allele created a donor splice site that causes abnormal splicing and the inclusion of 106 nt of intronic sequence in the transcript, leading to premature termination of the long cellular domain of the Ob-Rb splice form and loss of its signal transducing function. (J:31324, J:31327, J:31488) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	122 assay results 38 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	37 anatomical structure(s)

List all tumor models in MMHCdb carrying Leprdb

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 17 strains available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:	125 strains or lines available

Original:	J:5010 Hummel KP, et al., Diabetes, a new mutation in the mouse. Science. 1966 Sep 2;153(740):1127-8
All:	2084 reference(s)