Pax6<Sey> Spontaneous Allele Detail MGI Mouse (MGI:1856155)

Pax6^Sey
Spontaneous Allele Detail

Summary

Symbol:	Pax6^Sey
Name:	paired box 6; small eye
MGI ID:	MGI:1856155
Synonyms:	P5, Pax6-, Pax6^SeyEd, sey
Gene:	Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
Alliance:	Pax6^Sey page

Development of the Pax6^Sey/Pax6⁺ lens

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

Line selected for low body weight

Mutation
description

Allele Type:		Spontaneous
Mutation:		Single point mutation
		Mutation details: A G-to-T transversion in coding nucleotide 622 (NM_001244198.2) changes the glycine codon at position 208 to a stop codon (Gly208; NP_001231127.1), resulting in premature termination before the homeobox domain. (J:2301*)
Inheritance:		Semidominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	873 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	36 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 8 strains available Cell Lines: 0 lines available
Carrying any Pax6 Mutation:	94 strains or lines available

References

Original:	J:12101 Roberts RC, Small-eyes, a new dominant mutant in the mouse. Genet Res. 1967;9(1):121-122
All:	177 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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