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Tc
Radiation induced Allele Detail
Summary
Symbol: Tc
Name: brachyury, T-box transcription factor T; curtailed
MGI ID: MGI:1856185
Gene: T  Location: Chr17:8653255-8661328 bp, + strand  Genetic Position: Chr17, 4.92 cM
Alliance: Tc page
Mutation
origin
Strain of Origin:  (C3H/HeH x 101/H)F1
Mutation
description
Allele Type:    Radiation induced
Mutation:    Intragenic deletion
 
Mutation detailsSouthern analysis of genomic DNA showed that this allele does not comprise a deletion of flanking loci, D17Leh119II and D17RP17, as found for alleles Thp and TOrl. Sequencing genomic DNA from the open reading frame revealed a 19 bp deletion of GCACACGGTCTCAGCTGCC predicted to result in a protein truncated at the carboxyl-terminal end. (J:85398)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 74 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 20 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any T Mutation:  59 strains or lines available
Notes
Tc, curtailed, semidominant. Found among offspring from a cross between a multiple recessive testing stock, T stock, and a pup from an irradiated C3H/HeH female that had been impregnated by a 101/H male. Heterozygotes have complete or near-complete absence of the tail, absence of the odontoid process of the axis, absence of the nucleus pulposi of the intervertebral discs, a tendency for rib and vertebral fusions, and a slight decrease in average number of presacral vertebrae. They occasionally show paralysis of the hindlimbs and atresia ani. Homozygotes die at the same time as T/T embryos and are similar to them but more severely affected. Tc/T embryos are variable and intermediate between T/T and T c/T c (J:5003).
References
Original:  J:28887 Carter TC, et al., The genetic sensitivity to X-rays of mouse foetal gonads. Genet Res. 1960;1(3):351-5
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory