Kit<W-sh> Spontaneous Allele Detail MGI Mouse (MGI:1856265)

Kit^W-sh
Spontaneous Allele Detail

Summary

Symbol:	Kit^W-sh
Name:	KIT proto-oncogene receptor tyrosine kinase; sash
MGI ID:	MGI:1856265
Synonyms:	c-Kit^wsh, Sash, W-sh, W^sh, Wsh
Gene:	Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
Alliance:	Kit^W-sh page

Mutation
origin

Strain of Origin:

(C3H/HeH x 101/H)F1

Mutation
description

Allele Type:		Spontaneous
Mutation:		Inversion
		Kit^W-sh involves 32 genes/genome features (Tec, Slain2, Slc10a4 ...) View all
		Mutation details: The molecular mutation of this allele is an inversion located proximal to the Kit structural gene that disrupts 5' regulatory sequences. Transcripts were not detectable from this allele in cultured mast cells derived from homozygous mice. However, an analysis of embryonic expression revealed that ectopic expression of Kit occurred in homozygous mice and normal expression was ablated. (J:2535, J:6857, J:13166, J:25082, J:29686)
Inheritance:		Semidominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

93 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 11 strains available Cell Lines: 0 lines available
Carrying any Kit Mutation:	182 strains or lines available

References

Original:	J:6857 Lyon MF, et al., A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice. Genet Res. 1982 Jun;39(3):315-22
All:	336 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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