Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol: Gli3Xt-J Name: GLI-Kruppel family member GLI3; extra toes Jackson MGI ID: MGI:1856276 Synonyms: extra-toes J, Gli3-, Gli3delta, Gli3Xt, Gli3XtJ, xt, XtJ, XtJ Gene: Gli3  Location: Chr13:15638308-15904611 bp, + strand  Genetic Position: Chr13, 5.43 cM, cytoband A2 Alliance: Gli3Xt-J page

Gli3Xt-J/+ Show the 3 phenotype image(s) involving this allele.

Strain of Origin:

C3H/HeJ

Allele Type:    Spontaneous Mutation:    Intragenic deletion   Mutation details: Genomic sequencing and PCR analysis identified the mutation as a 51.5 kb deletion. The deleted region contains all Gli3 coding sequences 3' to exon 9, which includes sequences encoding some, but not all, of the zinc finger domains. This deletion results in the expression of an abnormal transcript that fuses Gli3 sequences to an exon belonging to an apparent LTR/MaLR repetitive element. However, this transcript lacks the sequences required for normal GLI3 activity. (J:4086, J:48982, J:76587) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1130 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	30 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Gli3 Mutation:	81 strains or lines available

Original:	J:78286 Dickie MM, Presumed recurrences of mutations. Mouse News Lett. 1967;36:60
All:	196 reference(s)