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Gli3Pdn
Spontaneous Allele Detail
Summary
Symbol: Gli3Pdn
Name: GLI-Kruppel family member GLI3; polydactyly Nagoya
MGI ID: MGI:1856282
Synonyms: Pdn
Gene: Gli3  Location: Chr13:15638308-15904611 bp, + strand  Genetic Position: Chr13, 5.43 cM, cytoband A2
Alliance: Gli3Pdn page
Mutation
origin
Strain of Origin:  Jcl:ICR
Mutation
description
Allele Type:    Spontaneous (Hypomorph)
Mutation:    Transposon insertion
 
Mutation details: This hypomorphic allele was shown to contain a 5442 bp early retrotransponson in intron 3 by PCR analysis. The transposon was similar to a known retrotransposon, MMY17106, containing 317 bp long terminal repeats followed by 6 bp target duplication sequences at each end. RT-PCR analysis of homozygous mutant mice has shown several species of aberrant transcripts and indicated that the amount of message present in homozygous mutant mice is approximately 20% of the wild-type level. (J:18650, J:53808, J:82981)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 109 assay results
In Structures Affected by this Mutation: 20 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gli3 Mutation:  81 strains or lines available
References
Original:  J:12736 Hayasaka I, et al., Polydactyly Nagoya, Pdn: A new mutant gene in the mouse. Jikken Dobutsu. 1980 Oct;29(4):391-5
All:  32 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory