Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: ApcMin Name: APC, WNT signaling pathway regulator; multiple intestinal neoplasia MGI ID: MGI:1856318 Synonyms: Apc-, Apc580S, Apcdelta850, ApcΔ850, Min, Min- Gene: Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM Alliance: ApcMin page

Rab25tm1Jrgo/Rab25tm1Jrgo ApcMin/Apc+ mice exhibit increased intestinal adenoma formation compared to ApcMin/Apc+ mice Show the 5 phenotype image(s) involving this allele.

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: A transversion point mutation that alters nucleotide 2549 from a T to an A (mRNA: NM_001360980.1; protein: NM_007462.3). This converts codon 850 from one encoding a leucine to a stop codon (p.Leu850*), truncating the expected polypeptide. (J:830) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	20 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

List all tumor models in MMHCdb carrying ApcMin

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:	158 strains or lines available

Original:	J:10209 Moser AR, et al., A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science. 1990 Jan 19;247(4940):322-4
All:	1091 reference(s)