Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Faslgld Name: Fas ligand; generalized lymphoproliferative disease MGI ID: MGI:1856384 Synonyms: CD95-, FasL-, gld, Tnfsf6gld Gene: Fasl  Location: Chr1:161608260-161616064 bp, - strand  Genetic Position: Chr1, 69.95 cM Alliance: Faslgld page

control and Faslgld/Faslgld Show the 1 phenotype image(s) involving this allele.

Strain of Origin:

C3H/HeJ

Allele Type:    Spontaneous Mutation:    Single point mutation   Mutation details: A T-to-C transition point mutation near the 3' end of the coding sequence causes a replacement of a highly conserved phenylalanine with a leucine at position 273 (p.F273L) in the extracellular region of the encoded protein. (J:17445) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

List all tumor models in MMHCdb carrying Faslgld

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Fasl Mutation:	37 strains or lines available

Original:	J:29572 Murphy ED, et al., Generalized lymphoproliferative disease (gld). Mouse News Lett. 1982;67:20-1
All:	366 reference(s)