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Egfrwa2
Spontaneous Allele Detail
Summary
Symbol: Egfrwa2
Name: epidermal growth factor receptor; waved 2
MGI ID: MGI:1856397
Synonyms: wa-2, wa2, waved2
Gene: Egfr  Location: Chr11:16702203-16868158 bp, + strand  Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
Alliance: Egfrwa2 page
Mammary gland histology of an Egfrwa2/Egfrwa2 mouse

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  STOCK ac
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA T-to-G transversion mutation in the sequences encoding the tyrosine kinase domain results in a substitution of a highly conserved valine with glycine at position 767 (P.V767G) in the third kinase subdomain. (J:16986)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 19 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Egfrwa2
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Egfr Mutation:  87 strains or lines available
Notes
Found by Keeler in an ``abnormal corpus callosum'' stock at the Bussey Institution.
References
Original:  J:13052 Keeler CE, A second rexoid coat character in the house mouse. J Hered. 1935;26(5):189-191
All:  71 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory