About   Help   FAQ
tw5
Spontaneous Allele Detail
Summary
Symbol: tw5
Name: t-complex; t, wild 5
MGI ID: MGI:1856570
Synonyms: tcl-w5, t-complex lethal w5
Gene: t  Location: unknown  Genetic Position: Chr17, Syntenic
Alliance: tw5 page
Mutation
origin
Strain of Origin:  wild-derived
Mutation
description
Allele Type:    Spontaneous
Mutations:    Inversion, Nucleotide repeat expansion
 
Mutation detailsThis t haplotype includes a mutation in Vps52, Vps52t-w5 that inserts 2 G nucleotides at the start of exon 2 in a stretch of consecutive G nucleotides (9 in the wild-type C57BL/6 sequence) resulting in a frameshift mutation that generates a premature termination codon. The mutation in Vsp52 is responsible for the embryonic lethal homozygous phenotype in this haplotype. (J:190873)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any t Mutation:  19 strains or lines available
Notes
This homozygous lethal allele originated in a mouse caught in the New York suburbs. It suppresses recombination and is a member of the complementation group: tw5 ,tw6 ,tw10 ,tw11 ,tw13 ,tw14 ,tw15 ,tw16 ,tw17 ,tw37 , tw38 ,tw39 ,tw41 ,tw46 ,tw47 ,tw74 ,tw75 ,tw80 ,tw81. T/tw5 phenotype is tail-less.
    Embryos homozygous for tw5 arrest at gastrulation and exhibit defects in proliferation/differentiation of embryonic ectoderm.
References
Original:  J:23652 Dunn LC, et al., Studies of the Genetic Variability in Wild Populations of House Mice. I. Analysis of Seven Alleles at Locus T. Genetics. 1956 May;41(3):344-52
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory