Lpin1<fld> Spontaneous Allele Detail MGI Mouse (MGI:1856603)

Lpin1^fld
Spontaneous Allele Detail

Summary

Symbol:	Lpin1^fld
Name:	lipin 1; fatty liver dystrophy
MGI ID:	MGI:1856603
Synonyms:	fld
Gene:	Lpin1 Location: Chr12:16585670-16696967 bp, - strand Genetic Position: Chr12, 7.9 cM
Alliance:	Lpin1^fld page

Lpin1^fld/Lpin1^fld and control

Show the 4 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

BALB/cByJ

Mutation
description

Allele Type:		Spontaneous
Mutations:		Insertion, Intragenic deletion, Inversion
		Lpin1^fld involves 1 genes/genome features (Lpin1) View all
		Mutation details: Three molecular changes have been identified in this allele. A 2 kb deletion encompasses exons 2 and 3 including the translation initiation sequence. An inversion exceeding 40 kb encompasses much of the coding region. An additional 0.5 kb sequence downstream of the inverted 40 kb has been duplicated and inserted in reverse orientation just upstream of this 40 kb inversion. Northern blots of adipose tissue extracts failed to detect mRNA from mice homozygous for this allele. (J:66739)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Lpin1 Mutation:	57 strains or lines available

References

Original:	J:64452 Sweet HO, et al., fld - fatty liver dystrophy. Mouse News Lett. 1988;81:69
All:	35 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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