Fgfr2<svs> Spontaneous Allele Detail MGI Mouse (MGI:1856633)

Fgfr2^svs
Spontaneous Allele Detail

Summary

Symbol:	Fgfr2^svs
Name:	fibroblast growth factor receptor 2; seminal vesicle shape
MGI ID:	MGI:1856633
Synonyms:	svs
Gene:	Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
Alliance:	Fgfr2^svs page

Mutation
origin

Strain of Origin:

CXB5/By

Mutation
description

Allele Type:		Spontaneous
Mutation:		Viral insertion
		Mutation details: An insertion of a 491-bp mouse leukemia virus long terminal repeat (MLV-LTR) sequence into intron 10 results in aberrant alternative splicing of the transcript with exclusion from most mature mutant mRNA species of exon 8IIIb, which encodes the domain required for specific binding to FGF ligands in developing prostate and seminal vesicle mesenchyme. (J:119935)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:	90 strains or lines available

Notes

This recessive autosomal mutation apparently occurred early in the inbreeding of the Essex CXB recombinant inbred lines, as the abnormality was not present in either of the parental strains, C57BL/6ByEss or BALB/cByEss, but is present in both CXBI/ByJax and CXBI/ByLac J:9441.

References

Original:	J:64453 Shukri N, et al., svs - seminal vesicle shape. Mouse News Lett. 1988;81:56
All:	4 reference(s)

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