t<w5G> Spontaneous Allele Detail MGI Mouse (MGI:1856718)

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t^w5G
Spontaneous Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	t^w5G
Name:	t-complex; t, wild 5G
MGI ID:	MGI:1856718
Gene:	t Location: unknown Genetic Position: Chr17, Syntenic
Alliance:	t^w5G page

Mutation
origin

Strain of Origin:

wild-derived

Mutation
description

Allele Type:		Spontaneous
Mutation:		Nucleotide repeat expansion
		Mutation details: This t haplotype includes a mutation in Vps52, Vps52^t-w5+Art that inserts a third G nucleotide, in addition to the 2 inserted in Vps52^t-w5, at the start of exon 2 in a stretch of consecutive G nucleotides (9 in the wild-type C57BL/6 sequence, 11 in Vps52^t-w5). The insertion of an additional G nucleotide restores the reading frame of Vps52 back to the wild-type frame. (J:190873)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any t Mutation:	19 strains or lines available

References

Original:	J:8713 Uehara H, et al., The molecular organization of the H-2K region of two t-haplotypes: implications for the evolution of genetic diversity. EMBO J. 1987 Jan;6(1):83-90
All:	4 reference(s)

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