Rab38<cht> Spontaneous Allele Detail MGI Mouse (MGI:1856819)

Rab38^cht
Spontaneous Allele Detail

Summary

Symbol:	Rab38^cht
Name:	RAB38, member RAS oncogene family; chocolate
MGI ID:	MGI:1856819
Synonyms:	chocolate, cht
Gene:	Rab38 Location: Chr7:88079481-88140780 bp, + strand Genetic Position: Chr7, 49.19 cM
Alliance:	Rab38^cht page

Brown coat color in Rab38^cht/Rab38^cht mice (right)

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:		Spontaneous
Mutation:		Single point mutation
		Mutation details: A G-to-T transversion mutation at coding nucleotide 56 (c.56G>T) in exon 1 results in a glycine to valine substitution in codon 19 of the gene (p.G19V). This mutation lies within the highly conserved phosphate/Mg²⁺ domain. (J:75774)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Rab38 Mutation:	15 strains or lines available

Notes

This allele has been maintained on the C57BL/6J background at The Jackson Laboratory since 1984 when it was first identified.

References

Original:	J:13967 MacPike A, et al., New coat color mutations, Dbr and cht. Mouse News Lett. 1984;70:86
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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