Lmf1<cld> Spontaneous Allele Detail MGI Mouse (MGI:1856820)

Lmf1^cld
Spontaneous Allele Detail

Summary

Symbol:	Lmf1^cld
Name:	lipase maturation factor 1; combined lipase deficiency
MGI ID:	MGI:1856820
Synonyms:	cld
Gene:	Lmf1 Location: Chr17:25798059-25881800 bp, + strand Genetic Position: Chr17, 12.7 cM, cytoband A3.3
Alliance:	Lmf1^cld page

Mutation
origin

Strain of Origin:

M. m. musculus (Northern Jutland, Denmark)

Mutation
description

Allele Type:		Spontaneous
Mutation:		Viral insertion
		Mutation details: This mutation was found as a "parasitic lethal" in t^w73 and recovered from the haplotype by recombination. A full-length murine endogenous retrovirus (MuERV) is inserted into intron 7. This results in the expression of an aberrant mRNA that contains sequences derived from exons 1-7, but is missing sequences derived from exons 8-11. 400 bp of viral sequence replaced the missing sequences in the mRNA. (J:115044, J:130178)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Lmf1 Mutation:	31 strains or lines available

Notes

Lmf1 t^w73lab is one of three spontaneous, recessive, lethal mutations found in a wild-derived t haplotype. The other mutations are t^w73 and t^w73lab.

References

Original:	J:7083 Paterniti JR Jr, et al., Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouse. Science. 1983 Jul 8;221(4606):167-9
All:	11 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24