Cacnb4<lh> Spontaneous Allele Detail MGI Mouse (MGI:1856936)

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Cacnb4^lh
Spontaneous Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Cacnb4^lh
Name:	calcium channel, voltage-dependent, beta 4 subunit; lethargic
MGI ID:	MGI:1856936
Synonyms:	beta4^lh, lh
Gene:	Cacnb4 Location: Chr2:52318332-52566816 bp, - strand Genetic Position: Chr2, 29.98 cM
Alliance:	Cacnb4^lh page

Mutation
origin

Strain of Origin:

BALB/cGn

Mutation
description

Allele Type:		Spontaneous
Mutation:		Insertion
		Mutation details: A four bp insertion that disrupts the consensus 5' splice site of intron A/B was identified. Reduced levels of transcripts are produced from this allele and are present at approximately 20% of the normal levels in homozygous mice. (J:38214)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	30 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Cacnb4 Mutation:	32 strains or lines available

References

Original:	J:28465 Dickie MM, Lethargic (lh). Mouse News Lett. 1964;30:31
All:	34 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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