Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Dock7m
Name:	dedicator of cytokinesis 7; misty
MGI ID:	MGI:1856946
Synonyms:	m
Gene:	Dock7  Location: Chr4:98824908-99009152 bp, - strand  Genetic Position: Chr4, 45.6 cM, cytoband C6
Alliance:	Dock7m page

Strain of Origin:

DBA/J

Allele Type:    Spontaneous Mutation:    Insertion   Mutation details: Crosses between mice homozygous for misty and for moonlight, which mapped to overlapping critical regions on Chr 4, demonstrated failure of the two mutations to complement one another. Once moonlight had been identified as a mutation of Dock7 (Dock7mnlt), sequence analysis of this gene from misty mice revealed a retrotransposon LTR insertion following nucleotide 2045 (numbering from the A of the transcription initiation codon) that interrupts exon 18 and shifts the reading frame after codon 682 so that ten incorrect amino acids are incorporated into the protein before its premature termination. (J:146458) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	10 assay results 10 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

List all tumor models in MMHCdb carrying Dock7m

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 14 strains available      Cell Lines: 0 lines available
Carrying any Dock7 Mutation:	111 strains or lines available

Original:	J:12159 Woolley GW, "Misty," a new coat color dilution in the mouse, Mus musculus. Am Naturalist. 1941;75:507-508
All:	83 reference(s)