Wnt3a<vt> Spontaneous Allele Detail MGI Mouse (MGI:1857088)

Wnt3a^vt
Spontaneous Allele Detail

Summary

Symbol:	Wnt3a^vt
Name:	wingless-type MMTV integration site family, member 3A; vestigial tail
MGI ID:	MGI:1857088
Synonyms:	vt
Gene:	Wnt3a Location: Chr11:59138859-59181578 bp, - strand Genetic Position: Chr11, 37.17 cM
Alliance:	Wnt3a^vt page

Wnt3a^vt/Wnt3a^vt

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

C57BR

Mutation
description

Allele Type:		Spontaneous (Hypomorph)
Mutation:		Undefined
		Mutation details: Examination of the Wnt3a gene by Southern blot, Northern blot on adult lung tissue and cDNA sequence analysis revealed no sign of an obvious mutation that could account for a mutant phenotype. However, this mutation and a targeted mutation, Wnt3a^tm1Amc, were demonstrated to be noncomplemeting alleles. Further evidence from whole mount in situ hybridization studies on embryos demonstrated that expression of the encoded protein is reduced in homozygous embryos, suggesting that this hypomorphic allele results from a mutation in a regulatory element. (J:31335)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	51 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Wnt3a Mutation:	26 strains or lines available

References

Original:	J:64271 Heston WE, vt - vestigial-tail. Mouse News Lett. 1951;4:11
All:	31 reference(s)

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