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Alox5tm1Fun
Targeted Allele Detail
Summary
Symbol: Alox5tm1Fun
Name: arachidonate 5-lipoxygenase; targeted mutation 1, Colin D Funk
MGI ID: MGI:1857125
Synonyms: 5-LO-, 5LO-, 5-LO KO, 5-LOX-, 5-LOX K/O, 5LX-
Gene: Alox5  Location: Chr6:116387038-116438139 bp, - strand  Genetic Position: Chr6, 53.79 cM
Alliance: Alox5tm1Fun page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:21372
Parent Cell Line:  D3H (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: Insertion of a neomycin resistance cassette into exon 6 disrupted the Alox5 gene. RT-PCR studies did not detect transcript in resident peritoneal macrophages of homozygous mutant mice. Western blot analysis of resident peritoneal macrophages of homozygous mutant mice did not detect ALOX5. (J:21372)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Alox5 Mutation:  49 strains or lines available
References
Original:  J:21372 Chen XS, et al., Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature. 1994 Nov 10;372(6502):179-82
All:  133 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory