Apoa1<tm1Unc> Targeted Allele Detail MGI Mouse (MGI:1857127)

Apoa1^tm1Unc
Targeted Allele Detail

Summary

Symbol:	Apoa1^tm1Unc
Name:	apolipoprotein A-I; targeted mutation 1, University of North Carolina
MGI ID:	MGI:1857127
Synonyms:	A1-, Apo A1^-, Apo A-1 KO, apoa1tm1unc, ApoA-I-
Gene:	Apoa1 Location: Chr9:46139928-46141767 bp, + strand Genetic Position: Chr9, 25.36 cM, cytoband A2-A4
Alliance:	Apoa1^tm1Unc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:2109
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A genomic fragment containing exon 2 was replaced by a neomycin resistance cassette. The protein was not detectable in plasma by Ouchterlony double-immunodiffusion tests in homozygous mice. (J:2109)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	3 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apoa1^tm1Unc

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Apoa1 Mutation:	15 strains or lines available

References

Original:	J:2109 Williamson R, et al., Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7134-8
All:	89 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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