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Bdkrb2tm1Jfh
Targeted Allele Detail
Summary
Symbol: Bdkrb2tm1Jfh
Name: bradykinin receptor, beta 2; targeted mutation 1, J Fred Hess
MGI ID: MGI:1857135
Synonyms: B2-, B2-KO, B2R-, BdkrB2, Bk2r-, Bk B2R-, rB2 -
Gene: Bdkrb2  Location: Chr12:105529485-105561496 bp, + strand  Genetic Position: Chr12, 55.76 cM
Alliance: Bdkrb2tm1Jfh page
Histological changes in the postischemic kidneys of wild type, Bdkrb2tm1Jfh/Bdkrb2tm1Jfh and MGI:3710159/MGI:3710159 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:25953
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin selection cassette replaced the entire coding sequences of the gene. Binding assays on membranes prepared from ileum tissue of homozygous mice confirmed that no functional protein is produced from this allele. (J:25953)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 13 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Bdkrb2 Mutation:  26 strains or lines available
References
Original:  J:25953 Borkowski JA, et al., Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. J Biol Chem. 1995 Jun 9;270(23):13706-10
All:  91 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory