Bmp4<tm1Blh> Targeted Allele Detail MGI Mouse (MGI:1857137)

Bmp4^tm1Blh
Targeted Allele Detail

Summary

Symbol:	Bmp4^tm1Blh
Name:	bone morphogenetic protein 4; targeted mutation 1, Brigid L Hogan
MGI ID:	MGI:1857137
Synonyms:	Bmp4^-, Bmp4^delta, Bmp4^tm1, Bmp-4^tm1blh
Gene:	Bmp4 Location: Chr14:46620982-46628126 bp, - strand Genetic Position: Chr14, 23.95 cM
Alliance:	Bmp4^tm1Blh page

Anterior eye segment abnormalities in Bmp4^tm1Blh/Bmp4⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:28717
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin selection cassette replaced a genomic fragment containing all of the coding sequence of the gene after the seventh codon of exon 1. An oligonucleotide encoding a stop codon in all three reading frames was also inserted into exon 2. (J:28717)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	90 assay results
In Structures Affected by this Mutation:	40 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Bmp4 Mutation:	23 strains or lines available

References

Original:	J:28717 Winnier G, et al., Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 1995 Sep 1;9(17):2105-16
All:	43 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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