Cd28<tm1Mak> Targeted Allele Detail MGI Mouse (MGI:1857150)

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Cd28^tm1Mak
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Cd28^tm1Mak
Name:	CD28 antigen; targeted mutation 1, Tak Mak
MGI ID:	MGI:1857150
Synonyms:	CD28^-, CD28KO
Gene:	Cd28 Location: Chr1:60785547-60812521 bp, + strand Genetic Position: Chr1, 30.52 cM, cytoband C1-C3
Alliance:	Cd28^tm1Mak page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:14194
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A genomic fragment containing part of exon 2 was replaced by a neomycin resistance cassette. Flow-cytometry analysis on peripheral blood lymphocytes demonstrated that the protein was not expressed in these cells in homozygous mice. (J:14194)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 12 strains available Cell Lines: 0 lines available
Carrying any Cd28 Mutation:	52 strains or lines available

References

Original:	J:14194 Shahinian A, et al., Differential T cell costimulatory requirements in CD28-deficient mice. Science. 1993 Jul 30;261(5121):609-12
All:	315 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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