Gzmb<tm1Ley> Targeted Allele Detail MGI Mouse (MGI:1857156)

About Help FAQ

Gzmb^tm1Ley
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Gzmb^tm1Ley
Name:	granzyme B; targeted mutation 1, Timothy J Ley
MGI ID:	MGI:1857156
Synonyms:	Granzyme B-, GrB KO, GrzB-, gzmB-, Gzmb-, Gzmb^-/+PGK-neo
Gene:	Gzmb Location: Chr14:56496295-56499717 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband D3
Alliance:	Gzmb^tm1Ley page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:23560
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A PGK-neomycin resistance cassette replaced a 350bp AvrII fragment starting within the 5' untranslated region (22 bp upstream from the initiation codon), extending through exon 1 and part of intron 1. (J:23560)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 7 strains available Cell Lines: 0 lines available
Carrying any Gzmb Mutation:	29 strains or lines available

References

Original:	J:23560 Heusel JW, et al., Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 1994 Mar 25;76(6):977-87
All:	108 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24