Dnmt1<tm1Jae> Targeted Allele Detail MGI Mouse (MGI:1857157)

Dnmt1^tm1Jae
Targeted Allele Detail

Summary

Symbol:	Dnmt1^tm1Jae
Name:	DNA methyltransferase 1; targeted mutation 1, Rudolf Jaenisch
MGI ID:	MGI:1857157
Synonyms:	Dmntⁿ, Dnmt1^N, Dnmt^N, MTase(-), Mtaseⁿ
Gene:	Dnmt1 Location: Chr9:20818501-20871084 bp, - strand Genetic Position: Chr9, 7.66 cM
Alliance:	Dnmt1^tm1Jae page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:1157
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Hypomorph)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Replacement of 900 bp, including the translation start site, with a neomycin cassette. This is a hypomorphic allele; enzyme activity levels have dropped to approximately 30% of the normal value. (J:1157)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	64 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dnmt1^tm1Jae

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Dnmt1 Mutation:	112 strains or lines available

References

Original:	J:1157 Li E, et al., Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 1992 Jun 12;69(6):915-26
All:	34 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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