Klf1<tm1Sho> Targeted Allele Detail MGI Mouse (MGI:1857162)

Klf1^tm1Sho
Targeted Allele Detail

Summary

Symbol:	Klf1^tm1Sho
Name:	Kruppel-like transcription factor 1 (erythroid); targeted mutation 1, Stuart Orkin
MGI ID:	MGI:1857162
Synonyms:	EKLF^-
Gene:	Klf1 Location: Chr8:85628611-85631920 bp, + strand Genetic Position: Chr8, 41.3 cM
Alliance:	Klf1^tm1Sho page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:25651
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance cassette replaced a portion of intron 2 and exon 2, which encodes the zinc-finger DNA-binding domain of the protein. No stable RNA for the targeted gene was detected by RNase protection using RNA from homozygous mutant embryos. (J:25651)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

52048 assay results
4 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Klf1 Mutation:	22 strains or lines available

References

Original:	J:25651 Perkins AC, et al., Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995 May 25;375(6529):318-22
All:	20 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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