En2<tm1Alj> Targeted Allele Detail MGI Mouse (MGI:1857164)

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En2^tm1Alj
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	En2^tm1Alj
Name:	engrailed 2; targeted mutation 1, Alexandra L Joyner
MGI ID:	MGI:1857164
Synonyms:	En2-, en-2^hd
Gene:	En2 Location: Chr5:28370692-28377164 bp, + strand Genetic Position: Chr5, 13.94 cM
Alliance:	En2^tm1Alj page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:67524
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance cassette replaced 1 kb of sequence containing 300 bp of intron and 700 bp of the homeobox exon. (J:67524)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	28 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any En2 Mutation:	104 strains or lines available

References

Original:	J:67524 Joyner AL, et al., Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science. 1991 Mar 8;251(4998):1239-43
All:	41 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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