Fcgr2b<tm1Ttk> Targeted Allele Detail MGI Mouse (MGI:1857166)

Fcgr2b^tm1Ttk
Targeted Allele Detail

Summary

Symbol:	Fcgr2b^tm1Ttk
Name:	Fc receptor, IgG, low affinity IIb; targeted mutation 1, Toshiyuki Takai
MGI ID:	MGI:1857166
Synonyms:	FcgammaRII, FcgammaRII-, FcgammaRII2B-, FcgammaRIIb^-, FcgammaRIIB^-, Fcgr2b^tm1Rav, FcgRIIB129^-, FcRIIB^-, IIB-, TAC264
Gene:	Fcgr2b Location: Chr1:170786186-170804116 bp, - strand Genetic Position: Chr1, 78.02 cM
Alliance:	Fcgr2b^tm1Ttk page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:31133
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A 2.3 kb genomic fragment containing the S1 and EC1 exons was replaced by a neomycin resistance cassette. Encoded transcript was undetectable in homozygous mutant mice via Northern blot analysis (data not shown). Western blot analysis of LPS-stimulated B cells derived from homozygous mice confirmed that no protein was made from this allele, and FACS analysis demonstrated that no functional protein was expressed on the cell surface of B cells in homozygous mice. (J:31133)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 7 strains available Cell Lines: 0 lines available
Carrying any Fcgr2b Mutation:	49 strains or lines available

References

Original:	J:31133 Takai T, et al., Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature. 1996 Jan 25;379(6563):346-9
All:	264 reference(s)

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