Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Fmr1tm1Cgr
Name:	fragile X messenger ribonucleoprotein 1; targeted mutation 1, Ben Oostra
MGI ID:	MGI:1857169
Synonyms:	Fmr1 KO, Fmr1tm4Cgr, FMRP KO, fmr-tm1Cgr, FraX
Gene:	Fmr1  Location: ChrX:67722147-67761569 bp, + strand  Genetic Position: ChrX, 34.83 cM
Alliance:	Fmr1tm1Cgr page

Germline Transmission:	Earliest citation of germline transmission: J:19220
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance gene was inserted into exon 5. RT-PCR analysis on testis RNA derived from hemizygous male mice demonstrated that no detectable transcript was produced from this allele, and western blot analysis on extracts of testes, liver, kidney and brain of hemizygous male mice confirmed that no stable encoded protein was made. (J:19220)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	112 assay results 9 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

List all tumor models in MMHCdb carrying Fmr1tm1Cgr

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Fmr1 Mutation:	29 strains or lines available

Original:	J:19220 Bakker CE, et al., Fmr1 knockout mice: a model to study fragile x mental retardation. The Dutch-Belgium Fragile X Consortium. Cell. 1994 Jul 15;78(1):23-33
All:	596 reference(s)