Fyn<tm1Sor> Targeted Allele Detail MGI Mouse (MGI:1857172)

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Fyn^tm1Sor
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Fyn^tm1Sor
Name:	Fyn proto-oncogene; targeted mutation 1, Philippe Soriano
MGI ID:	MGI:1857172
Synonyms:	fyn^-
Gene:	Fyn Location: Chr10:39245735-39441377 bp, + strand Genetic Position: Chr10, 20.51 cM
Alliance:	Fyn^tm1Sor page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:2242
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Replacement of a 3kb fragment containing the first coding exon of the gene with a neomycin cassette. (J:2242, J:97095)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Fyn Mutation:	39 strains or lines available

References

Original:	J:2242 Stein PL, et al., pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell. 1992 Sep 4;70(5):741-50
All:	168 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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