Htt<tm1Mem> Targeted Allele Detail MGI Mouse (MGI:1857180)

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Htt^tm1Mem
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Htt^tm1Mem
Name:	huntingtin; targeted mutation 1, Marcy E MacDonald
MGI ID:	MGI:1857180
Synonyms:	Hdh^-, Hdh^ex4/5, Hdh^null, R1Hdh4/5-1d1
Gene:	Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
Alliance:	Htt^tm1Mem page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:27183
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		A neomycin resistance cassette replaced exons 4 and 5 of the gene. (J:27183)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	27 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Htt Mutation:	178 strains or lines available

References

Original:	J:27183 Duyao MP, et al., Inactivation of the mouse Huntington's disease gene homolog Hdh. Science. 1995 Jul 21;269(5222):407-10
All:	13 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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