Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Il2tm1Hor
Name:	interleukin 2; targeted mutation 1, Ivan Horak
MGI ID:	MGI:1857191
Synonyms:	Il2-, IL-2-, IL-2 KO, IL-2null
Gene:	Il2  Location: Chr3:37174862-37180103 bp, - strand  Genetic Position: Chr3, 18.3 cM, cytoband B-C
Alliance:	Il2tm1Hor page

Germline Transmission:	Earliest citation of germline transmission: J:39989
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a neomycin-resistance gene into the third exon introduced several stop codons in all reading frames. (J:39989) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

22 anatomical structure(s)

List all tumor models in MMHCdb carrying Il2tm1Hor

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Il2 Mutation:	43 strains or lines available

Original:	J:39989 Schorle H, et al., Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature. 1991 Aug 15;352(6336):621-4
All:	195 reference(s)