Il2rb<tm1Mak> Targeted Allele Detail MGI Mouse (MGI:1857193)

Il2rb^tm1Mak
Targeted Allele Detail

Summary

Symbol:	Il2rb^tm1Mak
Name:	interleukin 2 receptor, beta chain; targeted mutation 1, Tak Mak
MGI ID:	MGI:1857193
Synonyms:	2Rbeta-, CD122^-, IL-2/IL-15Rbeta-, Il2rb^-, IL-2Rbeta-
Gene:	Il2rb Location: Chr15:78363456-78379471 bp, - strand Genetic Position: Chr15, 37.52 cM, cytoband E
Alliance:	Il2rb^tm1Mak page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:25940
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Insertion of a neomycin resistance cassette disrupted exon 6 of the gene, which encodes a region of extracellular domain proximal to the transmembrane region of the protein. (J:25940)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background
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hm1	Il2rb^tm1Mak/Il2rb^tm1Mak	B6.129-Il2rb^tm1Mak
hm2	Il2rb^tm1Mak/Il2rb^tm1Mak	C.129-Il2rb^tm1Mak
hm3	Il2rb^tm1Mak/Il2rb^tm1Mak	D2.129-Il2rb^tm1Mak
hm4	Il2rb^tm1Mak/Il2rb^tm1Mak	either: (involves: 129P2/OlaHsd) or (involves: 129S2/SvPas)
cx5	Il2rb^tm1Mak/Il2rb^tm1Mak Lck^tm1Mak/Lck^tm1Mak	involves: 129
cx6	Il2rb^tm1Mak/Il2rb^tm1Mak Rag2^tm1Fwa/Rag2^tm1Fwa	involves: 129 * 129S/SvEv

Phenotypes:

Affected Systems	hm1	hm2	hm3	hm4	cx5	cx6
show or hide all annotated terms Sex:
behavior/neurological				√
abnormal locomotor behavior				√
cellular	√	√
decreased T cell proliferation	√	√
embryo					√
abnormal maternal decidual layer morphology					√
absent uterine NK cells					√
endocrine/exocrine glands				√	√
thymus hypoplasia				√
abnormal sex gland morphology				√
absent uterine NK cells					√
absent endometrial glands					√
growth/size/body	√	√		√
weight loss				√
enlarged spleen	√	√		√
hematopoietic system	√	√	√	√	√	√
thymus hypoplasia				√
enlarged spleen	√	√		√
abnormal common myeloid progenitor cell morphology				√
increased susceptibility to autoimmune hemolytic anemia	√	√		√
increased erythroid progenitor cell number				√
increased granulocyte number				√
increased neutrophil cell number				√
abnormal mononuclear cell morphology				√
abnormal lymphocyte morphology	√	√
abnormal T cell clonal deletion		√	√
decreased double-positive T cell number				√
increased plasma cell number				√
decreased B cell number				√
decreased NK cell number						√
absent uterine NK cells					√
increased CD4-positive, alpha-beta T cell number				√
decreased CD8-positive, alpha-beta T cell number		√
increased CD8-positive, alpha-beta T cell number				√
decreased memory T cell number				√
decreased regulatory T cell number	√
increased activated T cell number				√
abnormal marginal zone B cell morphology		√
abnormal spleen periarteriolar lymphoid sheath morphology	√	√
abnormal B cell activation				√
increased IgE level				√
increased IgG1 level				√
abnormal T cell activation	√	√		√
decreased T cell proliferation	√	√
immune system	√	√	√	√	√	√
increased susceptibility to autoimmune hemolytic anemia	√	√		√
increased granulocyte number				√
increased neutrophil cell number				√
abnormal mononuclear cell morphology				√
abnormal lymphocyte morphology	√	√
abnormal T cell clonal deletion		√	√
decreased double-positive T cell number				√
increased plasma cell number				√
decreased B cell number				√
decreased NK cell number						√
absent uterine NK cells					√
increased CD4-positive, alpha-beta T cell number				√
decreased CD8-positive, alpha-beta T cell number		√
increased CD8-positive, alpha-beta T cell number				√
decreased memory T cell number				√
decreased regulatory T cell number	√
increased activated T cell number				√
abnormal marginal zone B cell morphology		√
abnormal B cell activation				√
increased IgE level				√
increased IgG1 level				√
abnormal T cell activation	√	√		√
decreased T cell proliferation	√	√
abnormal immune system organ morphology		√
thymus hypoplasia				√
enlarged spleen	√	√		√
abnormal spleen periarteriolar lymphoid sheath morphology	√	√
enlarged lymph nodes	√	√		√
increased anti-nuclear antigen antibody level				√
increased anti-double stranded DNA antibody level	√	√
liver inflammation		√
abnormal response to transplant	√
integument				√
abnormal hair texture				√
liver/biliary system		√
liver inflammation		√
mortality/aging		√		√
premature death		√		√
reproductive system				√	√
abnormal maternal decidual layer morphology					√
abnormal sex gland morphology				√
absent uterine NK cells					√
absent endometrial glands					√
abnormal endometrium morphology					√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available Cell Lines: 0 lines available
Carrying any Il2rb Mutation:	45 strains or lines available

Notes

Mice were generated from two independent embryonic stem cell lines: D3, derived from 129S2/SvPas; and E14, derived from 129P2/OlaHsd. (J:25940) Experiments described in J:25940 were performed using mice derived from the D3 ES cell line.

References

Original:	J:25940 Suzuki H, et al., Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science. 1995 Jun 9;268(5216):1472-6
All:	67 reference(s)

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