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Il2rbtm1Mak
Targeted Allele Detail
Summary
Symbol: Il2rbtm1Mak
Name: interleukin 2 receptor, beta chain; targeted mutation 1, Tak Mak
MGI ID: MGI:1857193
Synonyms: 2Rbeta-, CD122-, IL-2/IL-15Rbeta-, Il2rb-, IL-2Rbeta-
Gene: Il2rb  Location: Chr15:78363456-78379471 bp, - strand  Genetic Position: Chr15, 37.52 cM, cytoband E
Alliance: Il2rbtm1Mak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:25940
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Insertion of a neomycin resistance cassette disrupted exon 6 of the gene, which encodes a region of extracellular domain proximal to the transmembrane region of the protein. (J:25940)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Il2rb Mutation:  45 strains or lines available
Notes
Mice were generated from two independent embryonic stem cell lines: D3, derived from 129S2/SvPas; and E14, derived from 129P2/OlaHsd. (J:25940) Experiments described in J:25940 were performed using mice derived from the D3 ES cell line.
References
Original:  J:25940 Suzuki H, et al., Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science. 1995 Jun 9;268(5216):1472-6
All:  67 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory